Izvorni kod stranice (Metil-Co(III) metanol-specifični korinoid protein):koenzim M metiltransferaza

{{Infobox Enzim
| Name = (Metil-Co(III) metanol-specifični korinoid protein):koenzim M metiltransferaza
| EC_number = 2.1.1.246
| CAS_number = 
| IUBMB_EC_number = 2/1/1/246
| GO_code = 
| image = 
| width = 
| caption =
}}
'''(Metil-Co(III) metanol-specifični korinoid protein):koenzim M metiltransferaza''' ({{EC broj|2.1.1.246}}, ''metiltransferaza 2'', ''mtaA (gen)'') je [[enzim]] sa sistematskim imenom ''korinoidni protein specifičan za metilisani metanol:koenzim M metiltransferaza''.<ref>{{cite journal | title = Methylcobamide:coenzyme M methyltransferase isozymes from ''Methanosarcina barkeri''. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression |author = LeClerc, G.M. and Grahame, D.A. |journal = J. Biol. Chem. |date = 1996 |volume = 271 |pages = 18725-18731 |pmid = 8702528}}</ref><ref>{{cite journal | title = Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from ''Methanosarcina barkeri''. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the ''mtaA'' gene in ''Escherichia coli'' |author = Harms, U. and Thauer, R.K. |journal = Eur. J. Biochem. |date = 1996 |volume = 235 |pages = 653-659 |pmid = 8654414}}</ref><ref>{{cite journal | title = Methanol:coenzyme M methyltransferase from ''Methanosarcina barkeri''. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction |author = Sauer, K. and Thauer, R.K. |journal = Eur. J. Biochem. |date = 1997 |volume = 249 |pages = 280-285 |pmid = 9363780}}</ref><ref>{{cite journal | title = Methanol:coenzyme M methyltransferase from ''Methanosarcina barkeri''. Purification, properties and encoding genes of the corrinoid protein MT1 |author = Sauer, K., Harms, U. and Thauer, R.K. |journal = Eur. J. Biochem. |date = 1997 |volume = 243 |pages = 670-677 |pmid = 9057830}}</ref><ref>{{cite journal | title = Methanol:coenzyme M methyltransferase from ''Methanosarcina barkeri'' &ndash; substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin |author = Sauer, K. and Thauer, R.K. |journal = Eur. J. Biochem. |date = 1999 |volume = 261 |pages = 674-681 |pmid = 10215883}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: [metil-Co(III) metanol-specifični korinoidni protein] + [[koenzim M]] <math>\rightleftharpoons</math> metil-KoM + [Co(I) metanol-specifični korinoidni protein]

Ovaj enzim učestvuje u metanogenezi [[metanol]]a. On katalizuje transfer metil grupe sa korinoidnog proteina gde je vezana za kobaltni kofaktor, na [[koenzim M]], čime se formira supstrat za [[EC 2.8.4.1]], koenzim-B sulfoetiltiotransferazu, enzim koji katalizuje finalni korak metanogeneze.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|(methyl-Co(III)+methanol-specific+corrinoid+protein):coenzyme+M+methyltransferase}}

{{Enzimi}}

[[Kategorija:EC 2.1.1]]