Izvorni kod stranice (S)-2-hidroksipropilfosfonska kiselina epoksidaza

{{Infobox Enzim
| Name = (S)-2-hidroksipropilfosfonska kiselina epoksidaza
| EC_number = 1.14.19.7
| CAS_number = 
| IUBMB_EC_number = 1/14/19/7
| GO_code = 
| image = 
| width = 
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}}
'''(S)-2-hidroksipropilfosfonska kiselina epoksidaza''' ({{EC broj|1.14.19.7}}, ''HPP epoksidaza'', ''HppE'', ''2-hidroksipropilfosfonic kiselina epoksidaza'', ''Fom4'', ''(S)-2-hidroksipropilfosfonat epoksidaza'') je [[enzim]] sa sistematskim imenom ''(S)-2-hidroksipropilfosfonat,NADH:kiseonik epoksidaza''.<ref>{{cite journal | title = Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from ''Pseudomonas syringae'' |author = Munos, J.W., Moon, S.J., Mansoorabadi, S.O., Chang, W., Hong, L., Yan, F., Liu, A. and Liu, H.W. |journal = Biochemistry |date = 2008 |volume = 47 |pages = 8726-8735 |pmid = 18656958}}</ref><ref>{{cite journal | title = Determination of the substrate binding mode to the active site iron of (''S'')-2-hydroxypropylphosphonic acid epoxidase using <sup>17</sup>O-enriched substrates and substrate analogues |author = Yan, F., Moon, S.J., Liu, P., Zhao, Z., Lipscomb, J.D., Liu, A. and Liu, H.W. |journal = Biochemistry |date = 2007 |volume = 46 |pages = 12628-12638 |pmid = 17927218}}</ref><ref>{{cite journal | title = Cloning and nucleotide sequence of fosfomycin biosynthetic genes of ''Streptomyces wedmorensis'' |author = Hidaka, T., Goda, M., Kuzuyama, T., Takei, N., Hidaka, M. and Seto, H. |journal = Mol. Gen. Genet. |date = 1995 |volume = 249 |pages = 274-280 |pmid = 7500951}}</ref><ref>{{cite journal | title = Oxygenase activity in the self-hydroxylation of (''S'')-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin  biosynthesis |author = Liu, P., Mehn, M.P., Yan, F., Zhao, Z., Que, L., Jr. and Liu, H.W. |journal = J. Am. Chem. Soc. |date = 2004 |volume = 126 |pages = 10306-10312 |pmid = 15315444}}</ref><ref>{{cite journal | title = Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme |author = Higgins, L.J., Yan, F., Liu, P., Liu, H.W. and Drennan, C.L. |journal = Nature |date = 2005 |volume = 437 |pages = 838-844 |pmid = 16015285}}</ref><ref>{{cite journal | title = Initiating a crystallographic analysis of recombinant (''S'')-2-hydroxypropylphosphonic acid epoxidase from ''Streptomyces'' wedmorensis |author = Cameron, S., McLuskey, K., Chamberlayne, R., Hallyburton, I. and Hunter, W.N. |journal = Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |date = 2005 |volume = 61 |pages = 534-536 |pmid = 16511089}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: (S)-2-hidroksipropilfosfonat + NADH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> (1R,2S)-epoksipropilfosfonat + NAD<sup>+</sup> + 2H<sub>2</sub>O

Ovaj enzim sadrži u svakom monomeru jedan center gvožđa koje nije vezano za [[hem]].

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|(S)-2-hydroxypropylphosphonic+acid+epoxidase}}

{{Enzimi}}

[[Kategorija:EC 1.14.19]]