Izvorni kod stranice Žučna-kiselina 7alfa-dehidroksilaza

{{Infobox Enzim
| Name = Žučna-kiselina 7alfa-dehidroksilaza
| EC_number = 1.17.99.5
| CAS_number = 
| IUBMB_EC_number = 1/17/99/5
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Žučna-kiselina 7alfa-dehidroksilaza''' ({{EC broj|1.17.99.5}}, ''holatna 7alfa-dehidroksilaza'', ''7alfa-dehidroksilaza'', ''žučno kiselinska 7-dehidroksilaza'') je [[enzim]] sa sistematskim imenom ''dezoksiholat:NAD<sup>+</sup> oksidoreduktaza''.<ref>{{cite journal | title = Cofactor requirements for 7&alpha;-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, ''Eubacterium'' species V.P.I. 12708 | url = https://archive.org/details/sim_journal-of-lipid-research_1981-08_22_6/page/891 |author = White, B.A., Cacciapuoti, A.F., Fricke, R.J., Whitehead, T.R., Mosbach, E.H. and Hylemon, P.B. |journal = J. Lipid Res. |date = 1981 |volume = 22 |pages = 891-898 |pmid = 7276750}}</ref><ref>{{cite journal | title = Regulation of bile acid 7-dehydroxylase activity by NAD<sup>+</sup> and NADH in cell extracts of ''Eubacterium'' species V.P.I. 12708 | url = https://archive.org/details/sim_journal-of-lipid-research_1983-01_24_1/page/20 |author = White, B.A., Paone, D.A., Cacciapuoti, A.F., Fricke, R.J., Mosbach, E.H. and Hylemon, P.B. |journal = J. Lipid Res. |date = 1983 |volume = 24 |pages = 20-27 |pmid = 6833878}}</ref><ref>{{cite journal | title = Molecular cloning of bile acid 7-dehydroxylase from ''Eubacterium'' sp. strain VPI 12708 | url = https://archive.org/details/sim_journal-of-bacteriology_1987-04_169_4/page/1516 |author = Coleman, J.P., White, W.B. and Hylemon, P.B. |journal = J. Bacteriol. |date = 1987 |volume = 169 |pages = 1516-1521 |pmid = 3549693}}</ref><ref>{{cite journal | title = The enzymes, regulation, and genetics of bile acid synthesis | url = https://archive.org/details/sim_annual-review-of-biochemistry_2003_72/page/137 |author = Russell, D.W. |journal = Annu. Rev. Biochem. |date = 2003 |volume = 72 |pages = 137-174 |pmid = 12543708}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: (1) dezoksiholat + NAD<sup>+</sup> + H<sub>2</sub>O <math>\rightleftharpoons</math> holat + NADH + H<sup>+</sup>
: (2) lithoholat + NAD<sup>+</sup> +H<sub>2</sub>O <math>\rightleftharpoons</math> henodezoksiholat + NADH + H<sup>+</sup>

Ovaj enzim je visoko specifičan za [[Žučna kiselina|žučno-kiselinske]] supstrate. Za njegovo dejstvo je neophodna slobodna C-24 karboksilna grupa i nezaklonjena 7alfa-hidroksi grupa na B-prstenu [[steroid]] jezgra.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|Bile-acid+7alpha-dehydroxylase}}

{{Enzimi}}

[[Kategorija:EC 1.17.99]]