Izvorni kod stranice 18S rRNK (adenin1779-N6/adenin1780-N6)-dimetiltransferaza

{{Infobox Enzim
| Name = 18S rRNK (adenin<sup>1779</sup>-N<sup>6</sup>/adenin<sup>1780</sup>-N<sup>6</sup>)-dimetiltransferaza
| EC_number = 2.1.1.183
| CAS_number = 
| IUBMB_EC_number = 2/1/1/183
| GO_code = 
| image = 
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'''18S rRNK (adenin<sup>1779</sup>-N<sup>6</sup>/adenin<sup>1780</sup>-N<sup>6</sup>)-dimetiltransferaza''' ({{EC broj|2.1.1.183}}, ''18S rRNK dimetilaza Dim1p'', ''Dim1p'', ''ScDim1'', ''m2(6)A dimetilaza'', ''KIDIM1'') je [[enzim]] sa sistematskim imenom ''S-adenozil-L-metionin:18S rRNK (adenin<sup>1779</sup>-N<sup>6</sup>/adenin<sup>1780</sup>-N<sup>6</sup>)-dimetiltransferaza''.<ref>{{cite journal | title = The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast | url = https://archive.org/details/sim_genes-development_1995-10-15_9_20/page/n33 |author = Lafontaine, D., Vandenhaute, J. and Tollervey, D. |journal = Genes Dev. |date = 1995 |volume = 9 |pages = 2470-2481 |pmid = 7590228}}</ref><ref>{{cite journal | title = Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis | url = https://archive.org/details/sim_molecular-and-cellular-biology_1998-04_18_4/page/2360 |author = Lafontaine, D.L., Preiss, T. and Tollervey, D. |journal = Mol. Cell Biol. |date = 1998 |volume = 18 |pages = 2360-2370 |pmid = 9528805}}</ref><ref>{{cite journal | title = Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases |author = Pulicherla, N., Pogorzala, L.A., Xu, Z., O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Sia, E.A., Culver, G.M. and Rife, J.P. |journal = J. Mol. Biol. |date = 2009 |volume = 391 |pages = 884-893 |pmid = 19520088}}</ref><ref>{{cite journal | title = The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3&prime;-terminal loop of 18 S rRNA is essential in yeast |author = Lafontaine, D., Delcour, J., Glasser, A.L., Desgres, J. and Vandenhaute, J. |journal = J. Mol. Biol. |date = 1994 |volume = 241 |pages = 492-497 |pmid = 8064863}}</ref><ref>{{cite journal | title = Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution |author = O'Farrell, H.C., Pulicherla, N., Desai, P.M. and Rife, J.P. |journal = RNA |date = 2006 |volume = 12 |pages = 725-733 |pmid = 16540698}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: 4 S-adenozil-L-metionin + [[adenin]]<sup>1779</sup>/adenin<sup>1780</sup> u 18S rRNK <math>\rightleftharpoons</math> 4 S-adenozil-L-homocistein + N<sup>6</sup>-dimetiladenin<sup>1779</sup>/N<sup>6</sup>-dimetiladenin<sup>1780</sup> u 18S rRNK

DIM1 učestvuje u pre-rRNK transformacijama.

== Reference ==
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== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|18S+rRNA+(adenine1779-N6/adenine1780-N6)-dimethyltransferase}}

{{Enzimi}}

[[Kategorija:EC 2.1.1]]