Izvorni kod stranice 23S rRNK (adenin2085-N6)-dimetiltransferaza

{{Infobox Enzim
| Name = 23S rRNK (adenin<sup>2085</sup>-N<sup>6</sup>)-dimetiltransferaza
| EC_number = 2.1.1.184
| CAS_number = 
| IUBMB_EC_number = 2/1/1/184
| GO_code = 
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'''23S rRNK (adenin<sup>2085</sup>-N<sup>6</sup>)-dimetiltransferaza''' ({{EC broj|2.1.1.184}}, ''ErmC' metiltransferaza'', ''ermC metilaza'', ''ermC 23S rRNK metiltransferaza'', ''rRNK:m6A metiltransferaza ErmC' '', ''ErmC' '', ''rRNK metiltransferaza ErmC' '') je [[enzim]] sa sistematskim imenom ''S-adenozil-L-metionin:23S rRNK (adenin<sup>2085</sup>-N<sup>6</sup>)-dimetiltransferaza''.<ref>{{cite journal | title = Substrate requirements for ErmC&prime; methyltransferase activity | url = https://archive.org/details/sim_journal-of-bacteriology_1995-08_177_15/page/4327 |author = Zhong, P., Pratt, S.D., Edalji, R.P., Walter, K.A., Holzman, T.F., Shivakumar, A.G. and Katz, L. |journal = J. Bacteriol. |date = 1995 |volume = 177 |pages = 4327-4332 |pmid = 7543473}}</ref><ref>{{cite journal | title = Mono- and dimethylating activities and kinetic studies of the ''ermC'' 23 S rRNA methyltransferase |author = Denoya, C. and Dubnau, D. |journal = J. Biol. Chem. |date = 1989 |volume = 264 |pages = 2615-2624 |pmid = 2492520}}</ref><ref>{{cite journal | title = Site and substrate specificity of the ''ermC'' 23S rRNA methyltransferase |author = Denoya, C.D. and Dubnau, D. |journal = J. Bacteriol. |date = 1987 |volume = 169 |pages = 3857-3860 |pmid = 2440853}}</ref><ref>{{cite journal | title = Crystal structure of ErmC&prime;, an rRNA methyltransferase which mediates antibiotic resistance in bacteria |author = Bussiere, D.E., Muchmore, S.W., Dealwis, C.G., Schluckebier, G., Nienaber, V.L., Edalji, R.P., Walter, K.A., Ladror, U.S., Holzman, T.F. and Abad-Zapatero, C. |journal = Biochemistry |date = 1998 |volume = 37 |pages = 7103-7112 |pmid = 9585521}}</ref><ref>{{cite journal | title = The 2.2 &Aring; structure of the rRNA methyltransferase ErmC&prime; and its complexes with cofactor and cofactor analogs: implications for the reaction  mechanism |author = Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J. and Abad-Zapatero, C. |journal = J. Mol. Biol. |date = 1999 |volume = 289 |pages = 277-291 |pmid = 10366505}}</ref><ref>{{cite journal | title = Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC&prime; redefines the substrate-binding site and suggests a model for protein-RNA  interactions |author = Maravic, G., Bujnicki, J.M., Feder, M., Pongor, S. and Flogel, M. |journal = Nucleic Acids Res. |date = 2003 |volume = 31 |pages = 4941-4949 |pmid = 12907737}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: 2 S-adenozil-L-metionin + [[adenin]]<sup>2085</sup> u 23S rRNK <math>\rightleftharpoons</math> 2 S-adenozil-L-homocistein + N<sup>6</sup>-dimetiladenin<sup>2085</sup> u 23S rRNK

ErmC je metiltransferaza koja pruža otpornost na makrolid-linkozamid-streptograminsku B grupu [[antibiotik]]a tako što katalizuje metilaciju 23S rRNK na [[adenin]]u<sup>2085</sup>.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|23S+rRNA+(adenine2085-N6)-dimethyltransferase}}

{{Enzimi}}

[[Kategorija:EC 2.1.1]]