Izvorni kod stranice 3,4-Dihidroksi-2-butanon-4-fosfatna sintaza

{{Infobox Enzim
| Name = 3,4-Dihidroksi-2-butanon-4-fosfatna sintaza
| EC_number = 4.1.99.12
| CAS_number = 
| IUBMB_EC_number = 4/1/99/12
| GO_code = 
| image = PDB 1g58 EBI.jpg
| width = 
| caption =
}}
'''3,4-Dihidroksi-2-butanon-4-fosfatna sintaza''' ({{EC broj|4.1.99.12}}, ''DHBP sintaza'', ''L-3,4-dihidroksibutan-2-on-4-fosfat sintaza'') je [[enzim]] sa sistematskim imenom ''D-ribuloza 5-fosfat format-lijaza (formira L-3,4-dihidroksibutan-2-on 4-fosfat)''.<ref>{{cite journal | title = Studies on the 4-carbon precursor in the biosynthesis of riboflavin. Purification and properties of L-3,4-dihydroxy-2-butanone-4-phosphate  synthase |author = Volk, R. and Bacher, A. |journal = J. Biol. Chem. |date = 1990 |volume = 265 |pages = 19479-19485 |pmid = 2246238}}</ref><ref>{{cite journal | title = Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis |author = Liao, D.I., Calabrese, J.C., Wawrzak, Z., Viitanen, P.V. and Jordan, D.B. |journal = Structure |date = 2001 |volume = 9 |pages = 11-18 |pmid = 11342130}}</ref><ref>{{cite journal | title = The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies  reveal the location of the active site |author = Kelly, M.J., Ball, L.J., Krieger, C., Yu, Y., Fischer, M., Schiffmann, S., Schmieder, P., K&uuml;hne, R., Bermel, W., Bacher, A., Richter, G. and Oschkinat, H. |journal = Proc. Natl. Acad. Sci. USA |date = 2001 |volume = 98 |pages = 13025-13030 |pmid = 11687623}}</ref><ref>{{cite journal | title = Structural definition of the active site and catalytic mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase |author = Liao, D.I., Zheng, Y.J., Viitanen, P.V. and Jordan, D.B. |journal = Biochemistry |date = 2002 |volume = 41 |pages = 1795-1806 |pmid = 11827524}}</ref><ref>{{cite journal | title = Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of ''Methanococcus jannaschii'' |author = Fischer, M., R&ouml;misch, W., Schiffmann, S., Kelly, M., Oschkinat, H., Steinbacher, S., Huber, R., Eisenreich, W., Richter, G. and Bacher, A. |journal = J. Biol. Chem. |date = 2002 |volume = 277 |pages = 41410-41416 |pmid = 12200440}}</ref><ref>{{cite journal | title = Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from ''Methanococcus jannaschii'' in complex with divalent metal ions and the  substrate ribulose 5-phosphate: implications for the catalytic mechanism |author = Steinbacher, S., Schiffmann, S., Richter, G., Huber, R., Bacher, A. and Fischer, M. |journal = J. Biol. Chem. |date = 2003 |volume = 278 |pages = 42256-42265 |pmid = 12904291}}</ref><ref>{{cite journal | title = Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from ''Methanococcus jannaschii'' in complex with the substrate ribulose  5-phosphate |author = Steinbacher, S., Schiffmann, S., Bacher, A. and Fischer, M. |journal = Acta Crystallogr. D Biol. Crystallogr. |date = 2004 |volume = 60 |pages = 1338-1340 |pmid = 15213409}}</ref><ref>{{cite journal | title = Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of ''Candida albicans'' |author = Echt, S., Bauer, S., Steinbacher, S., Huber, R., Bacher, A. and Fischer, M. |journal = J. Mol. Biol. |date = 2004 |volume = 341 |pages = 1085-1096 |pmid = 15328619}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: D-ribuloza 5-fosfat <math>\rightleftharpoons</math> [[format]] + L-3,4-dihidroksibutan-2-on 4-fosfat

Za dejstvo ovog enzima je neophodan divalentni katjon, preferentno Mg<sup>2+</sup>.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|3,4-dihydroxy-2-butanone-4-phosphate+synthase}}

[[Kategorija:EC 4.1.99]]