Izvorni kod stranice 3-ketosteroid 9alfa-monooksigenaza

{{Infobox Enzim
| Name = 3-ketosteroid 9alfa-monooksigenaza
| EC_number = 1.14.13.142
| CAS_number = 
| IUBMB_EC_number = 1/14/13/142
| GO_code = 
| image = 
| width = 
| caption =
}}
'''3-ketosteroid 9alfa-monooksigenaza''' ({{EC broj|1.14.13.142}}, ''KshAB'', ''3-ketosteroid 9alfa-hidroksilaza'') je [[enzim]] sa sistematskim imenom ''androsta-1,4-dien-3,17-dion,NADH:kiseonik oksidoreduktaza (9alfa-hidroksilacija)''.<ref>{{cite journal | title = ''Rhodococcus rhodochrous'' DSM 43269 3-ketosteroid 9&alpha;-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity | url = https://archive.org/details/sim_applied-and-environmental-microbiology_2009-08_75_16/page/5300 |author = Petrusma, M., Dijkhuizen, L. and van der Geize, R. |journal = Appl. Environ. Microbiol. |date = 2009 |volume = 75 |pages = 5300-5307 |pmid = 19561185}}</ref><ref>{{cite journal | title = Characterization of 3-ketosteroid 9&alpha;-hydroxylase, a Rieske oxygenase in the cholesterol degradation pathway of ''Mycobacterium tuberculosis'' |author = Capyk, J.K., D'Angelo, I., Strynadka, N.C. and Eltis, L.D. |journal = J. Biol. Chem. |date = 2009 |volume = 284 |pages = 9937-9946 |pmid = 19234303}}</ref><ref>{{cite journal | title = Activity of 3-ketosteroid 9&alpha;-hydroxylase (KshAB) indicates cholesterol side chain and ring degradation occur simultaneously in ''Mycobacterium tuberculosis'' |author = Capyk, J.K., Casabon, I., Gruninger, R., Strynadka, N.C. and Eltis, L.D. |journal = J. Biol. Chem. |date = 2011 |volume =  |pages = - |pmid = 21987574}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: androsta-1,4-dien-3,17-dion + NADH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 9alfa-hidroksiandrosta-1,4-dien-3,17-dion + NAD<sup>+</sup> + H<sub>2</sub>O

Ovaj enzim učestvuje u holesterol degradaciji u nekoliko bakterijskih patogena, kao što je ''[[Mycobakterija tuberculosis]]''.

== Reference ==
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== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|3-ketosteroid+9alpha-monooxygenase}}

{{Enzimi}}

[[Kategorija:EC 1.14.13]]