Izvorni kod stranice A-N-acetilneuraminat a-2,8-sijaliltransferaza

{{Infobox Enzim
| Name = A-N-acetilneuraminat a-2,8-sijaliltransferaza
| EC_number = 2.4.99.8
| CAS_number = 67339-00-8
| IUBMB_EC_number = 2/4/99/8
| GO_code = 
| image = 
| width = 
| caption =
}}
'''A-N-acetilneuraminat a-2,8-sijaliltransferaza''' ({{EC broj|2.4.99.8}}, ''citidin monofosfoacetilneuraminat-gangliozid GM3'', ''alfa-2,8-sijaliltransferaza'', ''gangliozid GD3 sintaza'', ''gangliozid GD3 sintetaza sijaliltransferaza'', ''CMP-NeuAc:LM1(alfa2-8) sijaliltranferaza'', ''GD3 sintaza'', ''SAT-2'') je [[enzim]] sa sistematskim imenom ''CMP-N-acetilneuraminat:alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozid alfa-(2->8)-N-acetilneuraminiltransferaza''.<ref>{{cite journal | title = Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides |author = Eppler, M.C., Morr&eacute;, J.D. and Keenan, T.W. |journal = Biochim. Biophys. Acta |date = 1980 |volume = 619 |pages = 332-343 |pmid = 7407217}}</ref><ref>{{cite journal | title = Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain |author = Higashi, H., Basu, M. and Basu, S. |journal = J. Biol. Chem. |date = 1985 |volume = 260 |pages = 824-828 |pmid = 3838172}}</ref><ref>{{cite journal | title = CMP-NeuNAc:poly-&alpha;-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules |author = McCoy, R.D., Vimr, E.R. and Troy, F.A. |journal = J. Biol. Chem. |date = 1985 |volume = 260 |pages = 12695-12699 |pmid = 4044605}}</ref><ref>{{cite journal | title = 1a |author = Yohe, H.C. and Yu, R.K. In vitro biosynthesis of an isomer of brain trisialoganglioside, GT |journal = J. Biol. Chem. |date = 1980 |volume = 255 |pages = 608-613 |pmid = 6766128}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: CMP-N-acetilneuraminat + alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozil-R <math>\rightleftharpoons</math> CMP + alfa-N-acetilneuraminil-(2->8)-alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozil-R

[[Gangliozid]]i mogu da deluju kao akceptori.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|Alpha-N-acetylneuraminate+alpha-2,8-sialyltransferase}}

{{Enzimi}}

[[Kategorija:EC 2.4.99]]