Izvorni kod stranice Di-trans,poli-cis-dekaprenilcistransferaza

{{Infobox Enzim
| Name = Di-trans,poli-cis-dekaprenilcistransferaza
| EC_number = 2.5.1.31
| CAS_number = 52350-87-5
| IUBMB_EC_number = 2/5/1/31
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Di-trans,poli-cis-dekaprenilcistransferaza''' ({{EC broj|2.5.1.31}}, ''di-trans,poli-cis-undekaprenil-difosfat sintaza'', ''undekaprenil-difosfat sintaza'', ''baktoprenil-difosfatna sintaza'', ''UPP sintetaza'', ''undekaprenil difosfatna sintetaza'', ''undekaprenilna pirofosfat'', ''sintetaza'') je [[enzim]] sa sistematskim imenom ''(2E,6E)-farnezil-difosfat:izopentenil-difosfat cistransferaza (dodaje 8 izopentenilnih jedinica)''.<ref>{{cite journal | title = Undecaprenyl pyrophosphate synthetase from ''Lactobacillus plantarum'': a dimeric protein |author = Muth, J.D. and Allen, C.M. |journal = Arch. Biochem. Biophys. |date = 1984 |volume = 230 |pages = 49-60 |pmid = 6712246}}</ref><ref>{{cite journal | title = Prenyltransferases of ''Bacillus subtilis'': undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase |author = Takahashi, I. and Ogura, K. |journal = J. Biochem. (Tokyo) |date = 1982 |volume = 92 |pages = 1527-1537 |pmid = 6818223}}</ref><ref>{{cite journal | title = Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate:  roles of the metal ion and conserved residues in catalysis |author = Guo, R.T., Ko, T.P., Chen, A.P., Kuo, C.J., Wang, A.H. and Liang, P.H. |journal = J. Biol. Chem. |date = 2005 |volume = 280 |pages = 20762-20774 |pmid = 15788389}}</ref><ref>{{cite journal | title = Mechanism of product chain length determination and the role of a flexible loop in ''Escherichia coli'' undecaprenyl-pyrophosphate synthase catalysis |author = Ko, T.P., Chen, Y.K., Robinson, H., Tsai, P.C., Gao, Y.G., Chen, A.P., Wang, A.H. and Liang, P.H. |journal = J. Biol. Chem. |date = 2001 |volume = 276 |pages = 47474-47482 |pmid = 11581264}}</ref><ref>{{cite journal | title = Mutational analysis of allylic substrate binding site of ''Micrococcus luteus'' B-P 26 undecaprenyl diphosphate synthase |author = Fujikura, K., Zhang, Y.W., Fujihashi, M., Miki, K. and Koyama, T. |journal = Biochemistry |date = 2003 |volume = 42 |pages = 4035-4041 |pmid = 12680756}}</ref><ref>{{cite journal | title = Crystal structure of ''cis''-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase |author = Fujihashi, M., Zhang, Y.W., Higuchi, Y., Li, X.Y., Koyama, T. and Miki, K. |journal = Proc. Natl. Acad. Sci. USA |date = 2001 |volume = 98 |pages = 4337-4342 |pmid = 11287651}}</ref><ref>{{cite journal | title = Product distribution and pre-steady-state kinetic analysis of ''Escherichia coli'' undecaprenyl pyrophosphate synthase reaction |author = Pan, J.J., Chiou, S.T. and Liang, P.H. |journal = Biochemistry |date = 2000 |volume = 39 |pages = 10936-10942 |pmid = 10978182}}</ref><ref>{{cite journal | title = Significance of highly conserved aromatic residues in ''Micrococcus luteus'' B-P 26 undecaprenyl diphosphate synthase |author = Kharel, Y., Zhang, Y.W., Fujihashi, M., Miki, K. and Koyama, T. |journal = J. Biochem. |date = 2003 |volume = 134 |pages = 819-826 |pmid = 14769870}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: (2E,6E)-farnezil difosfat + 8 [[izopentenil difosfat]] <math>\rightleftharpoons</math> 8 [[difosfat]] + ditrans,oktacis-undekaprenil difosfat

Undekaprenil pirofosfatna sintaza katalizuje konsekutivne reakcije kondenzacije [[farnezil difosfat]]a sa osam izopentenilnih difosfata, u kojima se nove cis-dvostruke veze formiraju. Time se generiše undekaprenil difosfat koji služi kao [[lipid]]ni nosilac za peptidoglikansku sintezu bakterijskog ćelijskog zida.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|Ditrans,polycis-undecaprenyl-diphosphate+synthase+((2E,6E)-farnesyl-diphosphate+specific)}}

{{Enzimi}}

[[Kategorija:EC 2.5.1]]