Izvorni kod stranice Dolihil-P-Man:Man6GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza

{{Infobox Enzim
| Name = Dolihil-P-Man:Man6GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza
| EC_number = 2.4.1.259
| CAS_number = 
| IUBMB_EC_number = 2/4/1/259
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Dolihil-P-Man:Man6GlcNAc2-PP-dolihol alfa-1,2-manoziltransferaza''' ({{EC broj|2.4.1.259}}, ''ALG9'', ''ALG9 alfa1,2 manoziltransferaza'', ''dolihilfosfomanoza-zavisna ALG9 manoziltransferaza'', ''ALG9 manoziltransferaza'', ''Dol-P-Man:Man6GlcNAc2-PP-Dol alfa-1,2-manoziltransferaza'') je [[enzim]] sa sistematskim imenom ''dolihil beta-D-manozil fosfat:D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->3)-D-Man-alfa-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol alfa-1,2-manoziltransferaza''.<ref>{{cite journal | title = Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient |author = Vleugels, W., Keldermans, L., Jaeken, J., Butters, T.D., Michalski, J.C., Matthijs, G. and Foulquier, F. |journal = Glycobiology |date = 2009 |volume = 19 |pages = 910-917 |pmid = 19451548}}</ref><ref>{{cite journal | title = The accumulation of Man(6)GlcNAc(2)-''PP''-dolichol in the ''Saccharomyces cerevisiae'' &Delta;''alg9'' mutant reveals a regulatory role for the Alg3p &alpha;1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing |author = Cipollo, J.F. and Trimble, R.B. |journal = J. Biol. Chem. |date = 2000 |volume = 275 |pages = 4267-4277 |pmid = 10660594}}</ref><ref>{{cite journal | title = ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis |author = Frank, C.G. and Aebi, M. |journal = Glycobiology |date = 2005 |volume = 15 |pages = 1156-1163 |pmid = 15987956}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: dolihil beta-D-manozil fosfat + D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->3)-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol <math>\rightleftharpoons</math> D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol + [[dolihil fosfat]]

Tokom formiranja N-glikozilnih veza glikoproteina dolazi do uređivanja sklopa rasprostanjenih [[oligosaharida]] sa Glc3Man9GlcNAc2 osnovom na lipidnom nosiocu dolihil difosfatu.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|Dolichyl-P-Man:Man6GlcNAc2-PP-dolichol+alpha-1,2-mannosyltransferase}}

{{Enzimi}}

[[Kategorija:EC 2.4.1]]