Izvorni kod stranice Kob(I)irinska kiselina a,c-diamid adenoziltransferaza

{{Infobox Enzim
| Name = Kob(I)irinska kiselina a,c-diamid adenoziltransferaza
| EC_number = 2.5.1.17
| CAS_number = 37277-84-2
| IUBMB_EC_number = 2/5/1/17
| GO_code = 
| image = PDB 1g5t EBI.jpg
| width = 
| caption =
}}
'''Kob(I)irinska kiselina a,c-diamid adenoziltransferaza''' ({{EC broj|2.5.1.17}}, ''CobA'', ''CobO'', ''ATP:korinoidna adenoziltransferaza'', ''kob(I)alaminska adenoziltransferaza'', ''akvakob(I)alaminska adenoziltransferaza'', ''akvokob(I)alamin vitamin B12s adenoziltransferaza'', ''ATP:kob(I)alamin Cobeta-adenoziltransferaza'') je [[enzim]] sa sistematskim imenom ''ATP:kob(I)irinska kiselina-a,c-diamid Cobeta-adenoziltransferaza''.<ref>{{cite journal | title = Enzymatic conversion of vitamin B<sub>12s</sub> to a cobamide coenzyme, &alpha;-(5,6-dimethylbenzimidazolyl)deoxyadenosylcobamide (adenosyl-B<sub>12</sub>) |author = Vitols, E., Walker, G.A. and Huennekens, F.M. |journal = J. Biol. Chem. |date = 1966 |volume = 241 |pages = 1455-1461 |pmid = 5946606}}</ref><ref>{{cite journal | title = Three-dimensional structure of ATP:corrinoid adenosyltransferase from ''Salmonella typhimurium'' in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP |author = Bauer, C.B., Fonseca, M.V., Holden, H.M., Thoden, J.B., Thompson, T.B., Escalante-Semerena, J.C. and Rayment, I. |journal = Biochemistry |date = 2001 |volume = 40 |pages = 361-374 |pmid = 11148030}}</ref><ref>{{cite journal | title = An in vitro reducing system for the enzymic conversion of cobalamin to adenosylcobalamin |author = Fonseca, M.V. and Escalante-Semerena, J.C. |journal = J. Biol. Chem. |date = 2001 |volume = 276 |pages = 32101-32108 |pmid = 11408479}}</ref><ref>{{cite journal | title = Purification and initial characterization of the ATP:corrinoid adenosyltransferase encoded by the cobA gene of ''Salmonella typhimurium'' | url = https://archive.org/details/sim_journal-of-bacteriology_1995-02_177_4/page/921 |author = Suh, S. and Escalante-Semerena, J.C. |journal = J. Bacteriol. |date = 1995 |volume = 177 |pages = 921-925 |pmid = 7860601}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: (1) ATP + kob(I)irinska kiselina a,c-diamid <math>\rightleftharpoons</math> [[trifosfat]] + adenozilkob(III)irinska kiselina a,c-diamid
: (2) ATP + [[kobinamid]] <math>\rightleftharpoons</math> trifosfat + [[adenozilkobinamid]]

Korinoidna adenozilacija se odvija u tri stupnja: (i) redukcija Co(III) do Co(II) putem transvera jednog elektrona. To može da bude posredovano enzimom [[EC 1.16.1.3]], akvakabalaminska reduktaza ili neenzimatski u prisustvu dihidroflavinskih nukleotida. (ii) Co(II) se redukuje do Co(I) u drugom transferu jednog elektrona posredstvom enzima [[EC 1.16.1.4]], kob(II)alamin reduktaze i (iii) Co(I) izvodi nukleofilni napad na adenozilnu grupu ATP-a ostavljajući atom kobalta u Co(III) stanju ([[EC 2.5.1.17]]).

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|Cob(I)yrinic+acid+a,c-diamide+adenosyltransferase}}

{{Enzimi}}

[[Kategorija:EC 2.5.1]]