Izvorni kod stranice Masna-kiselina peroksigenaza

{{Infobox Enzim
| Name = Masna-kiselina peroksigenaza
| EC_number = 1.11.2.4
| CAS_number = 
| IUBMB_EC_number = 1/11/2/4
| GO_code = 
| image = 
| width = 
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}}
'''Masna-kiselina peroksigenaza''' ({{EC broj|1.11.2.4}}, ''masno kiselinska hidroksilaza (nespecifična)'', ''P450 peroksigenaza'', ''CYP152A1'', ''P450BS'', ''P450SPalfa'') je [[enzim]] sa sistematskim imenom ''masna kiselina:hidroperoksid oksidoreduktaza (RH-hidroksilacija)''.<ref>{{cite journal | title = Direct involvement of hydrogen peroxide in bacterial &alpha;-hydroxylation of fatty acid | url = https://archive.org/details/sim_febs-letters_1996-05-20_386_2-3_0/page/n165 |author = Matsunaga, I., Yamada, M., Kusunose, E., Nishiuchi, Y., Yano, I. and Ichihara, K. |journal = FEBS Lett. |date = 1996 |volume = 386 |pages = 252-254 |pmid = 8647293}}</ref><ref>{{cite journal | title = Further characterization of hydrogen peroxide-dependent fatty acid &alpha;-hydroxylase from ''Sphingomonas paucimobilis'' |author = Matsunaga, I., Yamada, M., Kusunose, E., Miki, T. and Ichihara, K. |journal = J. Biochem. |date = 1998 |volume = 124 |pages = 105-110 |pmid = 9644252}}</ref><ref>{{cite journal | title = Characterization of the ''ybdT'' gene product of ''Bacillus subtilis'': novel fatty acid &beta;-hydroxylating cytochrome ''P''<sub>450</sub> | url = https://archive.org/details/sim_lipids_1999-08_34_8/page/841 |author = Matsunaga, I., Ueda, A., Fujiwara, N., Sumimoto, T. and Ichihara, K. |journal = Lipids |date = 1999 |volume = 34 |pages = 841-846 |pmid = 10529095}}</ref><ref>{{cite journal | title = Unique heme environment at the putative distal region of hydrogen peroxide-dependent fatty acid &alpha;-hydroxylase from ''Sphingomonas paucimobilis'' (peroxygenase ''P''<sub>450</sub>SP&alpha;) |author = Imai, Y., Matsunaga, I., Kusunose, E. and Ichihara, K. |journal = J. Biochem. |date = 2000 |volume = 128 |pages = 189-194 |pmid = 10920253}}</ref><ref>{{cite journal | title = Enzymatic reaction of hydrogen peroxide-dependent peroxygenase cytochrome ''P''<sub>450</sub>s: kinetic deuterium isotope effects and analyses by resonance Raman  spectroscopy |author = Matsunaga, I., Yamada, A., Lee, D.S., Obayashi, E., Fujiwara, N., Kobayashi, K., Ogura, H. and Shiro, Y. |journal = Biochemistry |date = 2002 |volume = 41 |pages = 1886-1892 |pmid = 11827534}}</ref><ref>{{cite journal | title = Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome ''P''<sub>450</sub> from ''Bacillus subtilis''. Crystallographic,  spectroscopic, and mutational studies |author = Lee, D.S., Yamada, A., Sugimoto, H., Matsunaga, I., Ogura, H., Ichihara, K., Adachi, S., Park, S.Y. and Shiro, Y. |journal = J. Biol. Chem. |date = 2003 |volume = 278 |pages = 9761-9767 |pmid = 12519760}}</ref><ref>{{cite journal | title = Peroxide-utilizing biocatalysts: structural and functional diversity of heme-containing enzymes |author = Matsunaga, I. and Shiro, Y. |journal = Curr. Opin. Chem. Biol. |date = 2004 |volume = 8 |pages = 127-132 |pmid = 15062772}}</ref><ref>{{cite journal | title = Aromatic C-H bond hydroxylation by ''P''<sub>450</sub> peroxygenases: a facile colorimetric assay for monooxygenation activities of enzymes based on  Russig&#8217;s blue formation |author = Shoji, O., Wiese, C., Fujishiro, T., Shirataki, C., Wunsch, B. and Watanabe, Y. |journal = J. Biol. Inorg. Chem. |date = 2010 |volume = 15 |pages = 1109-1115 |pmid = 20490877}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: masna kiselina + H<sub>2</sub>O<sub>2</sub> <math>\rightleftharpoons</math> 3- ili 2-hidroksi masna kiselina + H<sub>2</sub>O

Ovaj citosolni [[hem]]-[[tiol]]atni protein je sekventno homologan sa P450 monooksigenazama. Za njegov rad nisu neophodni NAD(P)H, [[dioksigen]] i specifične reduktaze. Enzime ovog tipa formiraju bakterije (e.g. ''[[Sphingomonas paucimobilis]]'', ''[[Bacillus subtilis]]'').

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|Fatty-acid+peroxygenase}}

{{Enzimi}}

[[Kategorija:EC 1.11.2]]