Izvorni kod stranice Metilentetrahidrofolat—tRNK-(uracil-5-)-metiltransferaza

{{Infobox Enzim
| Name = Metilentetrahidrofolat—tRNK-(uracil-5-)-metiltransferaza
| EC_number = 2.1.1.74
| CAS_number = 56831-74-4
| IUBMB_EC_number = 2/1/1/74
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Metilentetrahidrofolat—tRNK-(uracil-5-)-metiltransferaza''' ({{EC broj|2.1.1.74}}, ''folat-zavisna ribotimidilna sintaza'', ''metilintetrahidrofolatni-transfer ribonukleatni uracil 5-metiltransferaza'', ''5,10-metilintetrahidrofolat:tRNK-UPsiC (uracil-5-)-metil-transferaza'', ''5,10-metilintetrahidrofolat:tRNK (uracil-5-)-metil-transferaza'', ''TrmFO'', ''folat/FAD-zavisni tRNK T54 metiltransferaza'') je [[enzim]] sa sistematskim imenom ''5,10-metilintetrahidrofolat:tRNK (uracil54-C5)-metiltransferaza''.<ref>{{cite journal | title = Methylenetetrahydrofolate-dependent biosynthesis of ribothymidine in transfer RNA of ''Streptococcus faecalis''. Evidence for reduction of the 1-carbon unit by FADH<sub>2</sub> |author = Delk, A.S., Nagle, D.P., Jr. and Rabinowitz, J.C. |journal = J. Biol. Chem. |date = 1980 |volume = 255 |pages = 4387-4390 |pmid = 6768721}}</ref><ref>{{cite journal | title = Major identity determinants for enzymatic formation of ribothymidine and pseudouridine in the T&Psi;-loop of yeast tRNAs |author = Becker, H.F., Motorin, Y., Sissler, M., Florentz, C. and Grosjean, H. |journal = J. Mol. Biol. |date = 1997 |volume = 274 |pages = 505-518 |pmid = 9417931}}</ref><ref>{{cite journal | title = Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase |author = Nishimasu, H., Ishitani, R., Yamashita, K., Iwashita, C., Hirata, A., Hori, H. and Nureki, O. |journal = Proc. Natl. Acad. Sci. USA |date = 2009 |volume = 106 |pages = 8180-8185 |pmid = 19416846}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: 5,10-metilintetrahidrofolat + [[uridin]]<sup>54</sup> unutar tRNK + FADH<sub>2</sub> <math>\rightleftharpoons</math> [[tetrahidrofolat]] + 5-metiluridin<sup>54</sup> unutar tRNK + FAD

Do 25% baza funkcionalne [[tRNK]] je posttranslaciono modifikovano ili hipermodifikovano. Jedna od skoro universalnih posttranslacionih modifikacija je konverzija U<sup>54</sup> u [[ribotimidin]]u u TPsiC petlji.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|Methylenetetrahydrofolate—tRNA-(uracil54-C5)-methyltransferase+(FADH2-oxidizing)}}

{{Enzimi}}

[[Kategorija:EC 2.1.1]]