Izvorni kod stranice Natrijum fluoracetat

{{chembox-lat
|   Name = {{PAGENAME}}
|   ImageFile = Sodium-fluoroacetate-2D-skeletal.png
|   ImageSize = 180px
|   ImageFile1 = Sodium-fluoroacetate-xtal-3D-SF.png
|   ImageSize1 = 200px
|   IUPACName = Sodium 2-fluoroacetate
|   OtherNames = 1080<br /> SFA<br /> Sodium monofluoroacetate
| Section1 = {{Chembox Identifiers-lat
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 369611
| ChemSpiderID = 5893
| InChI = 1/C2H3FO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
| InChIKey = JGFYQVQAXANWJU-REWHXWOFAP
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 38699
| SMILES = [Na+].[O-]C(=O)CF
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C2H3FO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
|  Beilstein = 
|  Gmelin = 
|  3DMet = 
| StdInChIKey = JGFYQVQAXANWJU-UHFFFAOYSA-M
| CASNo_Ref = {{cascite|changed|??}}
| CASNo = 62-74-8
| RTECS = AH9100000
| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG = C18588
| PubChem = 16212360
  }}
| Section2 = {{Chembox Properties-lat
|   Formula = NaFC<sub>2</sub>H<sub>2</sub>O<sub>2</sub>
|   MolarMass = 100.0 g/mol
|   Appearance = pahuljast, bezbojan ili beo prah
|   Solubility = rastvorna so
|   MeltingPt = 200&nbsp;°C (325.15 K)
|   BoilingPt = razlaže se
  }}
| Section3 = {{Chembox Structure-lat
|   MolShape =
|   Coordination =
|   CrystalStruct =
|   Dipole =
  }}
| Section7 = {{Chembox Hazards-lat
|   ExternalMSDS =
|   MainHazards = Toksičano, zapalivo jedinjenje
|   FlashPt = ? 
|   RSPhrases = {{R26}} {{R27}} {{R28}}
|   LD50 = 0.1–5.0 mg/kg (oralno kod različitih vrsta pacova i miševa)<ref name=kalmbach>{{cite journal |author=Kalmbach ER |title=Ten-Eighty, a War-Produced Rodenticide|url=https://archive.org/details/sim_science_1945-08-31_102_2644/page/n18 |journal=Science |volume=102 |issue=2644 |pages=232–3 |year=1945 |pmid= 17778513|doi=10.1126/science.102.2644.232}}</ref><ref name="Proudfoot">{{cite journal |author=Proudfoot AT, Bradberry SM, Vale JA |title=Sodium fluoroacetate poisoning |journal=Toxicol Rev |volume=25 |issue=4 |pages=213–9 |year=2006 |pmid=17288493 |doi=10.2165/00139709-200625040-00002}}</ref>
  }}
| Section8 = {{Chembox Related-lat
|   OtherAnions =
|   OtherCations =
|   OtherCpds =
  }}
}}

'''Natrijum fluoracetat''' (takođe poznat i kao '''natrijum monofluoracetat''') je [[sol|so]] [[natrij]]uma sa [[fluoracetatna kiselina|fluoracetatnom kiselinom]]. To je bezbojano, veoma otrovano jedinjenje.

== Dobivanje ==
Natrijum fluoracetat se dobija pri reakciji [[natrijum hidroksid]]a, [[natrijum karbonat]]a ili [[natrijum hidrogenkarbonat|natrijum bikarbonata]], sa [[fluoracetatna kiselina|fluoracetatnom kiselinom]]:

:<math>\mathrm{NaOH + CH_2FCOOH \longrightarrow CH_2FCOONa + H_2O}</math>

:<math>\mathrm{Na_2CO_3 + 2 \ CH_2FCOOH \longrightarrow\ }</math> <math>\mathrm{2\ CH_2FCOONa + CO_2 + H_2O}</math>

:<math>\mathrm{NaHCO_3 + CH_2FCOOH \longrightarrow\ }</math> <math>\mathrm{\ CH_2FCOONa + CO_2 + H_2O}</math>

== Osobine ==
Natrijum fluoracetat je prah bez boje i mirisa, koji je malo rastvorljiv u vodi. Njegova tačka topljenja iznosi oko 200&nbsp;°C. Otrovan je za [[miš]]eve (oralno) u dozi od 0,1&nbsp;mg/kg<ref>{{cite journal |author=Ward JC |title=Rodent control with 1080, ANTU, and other war-developed toxic agents |journal=Am. J. Public Health Nations Health |volume=36 |year=1946 |pages=1427–31}}</ref><ref>{{cite journal |author=Yakkyoku |title=- |journal=Pharmacy |volume=28 |year=1977 |pages=329–39 }}{{ja icon}}</ref>

== Rasprostranjenost ==

Natrijum fluoroacetat je široko rasprostranjeno jedinjenje, mada je obično prisutno u veoma niskim koncentracijama. Moguće je potvrditi tragove ove soli čak i u listovima [[čaj]]a.<ref>{{cite journal |author=Vartiainen T, Kauranen P |title=The determination of traces of fluoroacetic acid by extractive alkylation, pentafluorobenzylation and capillary gas chromatography-mass spectrometry |journal=Anal. Chim. Acta |volume=157 |year=1984 |pages=91–97}}</ref> Ova so se može pronaći u preko 40 biljnih vrsta u [[Australija|Australiji]], [[Brazil]]u i [[Afrika|Africi]]. Na primer, ima je u listovima [[Južna Afrika|južnoafričke]] [[biljka|biljke]] zvane ''Gifblaar'' ({{jez-lat-lat|Dichapetalum cymosum}}). Odgovorna je za mnogobrojne smrtne slučajeve. Postoje podaci da je jedan list ove biljke dovoljan da se usmrti [[ovca]].<ref>{{cite web |url=http://www.chab.ethz.ch/publicrelations/publikationen/molmix/mm06/mm6_togni.pdf |author=ETH Cirih; Brauckmann B |title=Eingefügtes Fluor führt zu ganz neuen Substanzeigenschaften}} {{De}}</ref> [[Smrt]]onosna doza za čovjeka iznosi oko 5 do 10&nbsp;mg/kg tjelesne mase.<ref>{{cite web |url=http://www.fluoridealert.org/pesticides/sodium.fluoroacetate-page.htm |title=Fluoridealert.org - Sodium fluoroacetate |access-date=2013-05-07 |archive-date=2013-09-20 |archive-url=https://web.archive.org/web/20130920074902/http://www.fluoridealert.org/pesticides/sodium.fluoroacetate-page.htm }} {{en}}</ref> Manje doze mogu dovesti do oštećenja organa koji imaju veće energetske zahteve ([[mozak]], [[srce]] i [[pluća]]).<ref>{{cite journal |author=Hüter F |title=Moderne Nagetiervertilgungsmittel |journal=Journal of Pest Science |volume=23 |year=1950 |pages=49–51 }}</ref><ref>{{cite journal |author=Goh CS, et.al. |title=Sodium monofluoroacetate (Compound 1080) poisoning in dogs. |journal=Aust Vet J.'' |volume=83 |year=2005 |pages=474–479 |pmid=16119418 }}</ref>

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}
{{reflist|2}}
{{-}}
{{Jedinjenja natrijuma-lat}}

[[Kategorija:Jedinjenja natrijuma]]
[[Kategorija:Acetati]]
[[Kategorija:Inhibitori lijaze]]