Izvorni kod stranice Peptidilna-glutamatna 4-karboksilaza

{{Infobox Enzim
| Name = Peptidilna-glutamatna 4-karboksilaza
| EC_number = 4.1.1.90
| CAS_number = 
| IUBMB_EC_number = 4/1/1/90
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Peptidilna-glutamatna 4-karboksilaza''' ({{EC broj|4.1.1.90}}, ''vitamin K-zavisna karboksilaza'', ''gama-glutamil karboksilaza'') je [[enzim]] sa sistematskim imenom ''peptidil-glutamat 4-karboksilaza (2-metil-3-fitil-1,4-naftohinon-epoksidacija)''.<ref>{{cite journal | title = Vitamin K and energy transduction: a base strength amplification mechanism |author = Dowd, P., Hershline, R., Ham, S.W. and Naganathan, S. |journal = Science |date = 1995 |volume = 269 |pages = 1684-1691 |pmid = 7569894}}</ref><ref>{{cite journal | title = Vitamin K-dependent biosynthesis of &gamma;-carboxyglutamic acid |author = Furie, B., Bouchard, B.A. and Furie, B.C. |journal = Blood |date = 1999 |volume = 93 |pages = 1798-1808 |pmid = 10068650}}</ref><ref>{{cite journal | title = Bronsted analysis reveals Lys<sup>218</sup> as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent  protein carboxylation |author = Rishavy, M.A., Hallgren, K.W., Yakubenko, A.V., Shtofman, R.L., Runge, K.W. and Berkner, K.L. |journal = Biochemistry |date = 2006 |volume = 45 |pages = 13239-13248 |pmid = 17073445}}</ref><ref>{{cite journal | title = Reaction mechanism of the vitamin K-dependent glutamate carboxylase: a computational study |author = Silva, P.J. and Ramos, M.J. |journal = J. Phys. Chem. B |date = 2007 |volume = 111 |pages = 12883-12887 |pmid = 17935315}}</ref><ref>{{cite journal | title = The stereochemistry of hydrogen abstraction in vitamin K-dependent carboxylation |author = Decottignies-Le Mar&eacute;chal, P., Ducrocq, C., Marquet, A. and Azerad, R. |journal = J. Biol. Chem. |date = 1984 |volume = 259 |pages = 15010-15012 |pmid = 6150930}}</ref><ref>{{cite journal | title = Vitamin K dependent carboxylation: determination of the stereochemical course using 4-fluoroglutamyl-containing substrate |author = Dubois, J., Dugave, C., Foures, C., Kaminsky, M., Tabet, J.C., Bory, S., Gaudry, M. and Marquet, A. |journal = Biochemistry |date = 1991 |volume = 30 |pages = 10506-10512 |pmid = 1931973}}</ref> Ovaj enzim [[Kataliza|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: peptidil-4-karboksiglutamat + 2,3-epoksifilohinon + H<sub>2</sub>O <math>\rightleftharpoons</math> peptidil-glutamat + CO<sub>2</sub> + O<sub>2</sub> + [[filohinon]]

Ovaj enzim može da koristi razne derivate vitamina K, uključujući menahinon.

== Reference ==
{{reflist}}

== Literatura ==
{{refbegin|2}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{CopelandEvaluationOfEnzymeInhibitors2nd}}
* {{MichalBiochemicalPathways}}
{{refend}}

== Vanjske veze ==
* {{MeshName|Peptidyl-glutamate+4-carboxylase}}

{{Enzimi}}

[[Kategorija:EC 4.1.1]]